SLPI and Sepsis: In the spleen tissue from sepsis models, SLPI mRNA expression was significantly elevated in macrophages (cluster #4), NK cells (cluster #14), T cells (cluster #1), endothelial cells (clusters #2 and #9), monocytes (cluster #5), chondrocytes (cluster #6), and B cells (clusters #8 and #12) (p ≤ 0.001) (Figures 6c, 6d, and 6e).