APOE and cardiovascular disorder: Here, we conducted a small study to explore the use of a CMP in preserving vascular architecture in systemic cardiovascular disease using an established model of atherosclerosis that uses streptozocin (STZ) to accelerate EC dysfunction in ApoE−/− (apolipoprotein E) mice maintained on a high-fat diet (Tucureanu et al., 2019; Ganbaatar et al., 2020).