FUNDC1-mediated mitochondrial autophagy was found to play a role in MPP + -treated SH-SY5Y cells and MPTP-induced PD mice and the application of a FUNDC1 inhibitor resulted in suppression of inflammatory responses and reduction of nigrostriatal dopaminergic neuron death in a PD model, suggesting that inhibition of FUNDC1 could exert neuroprotective effects against PD (Zhang, 2024). This evidence concerns the gene FUNDC1 and Parkinson disease.