OPA1 and Alzheimer disease: Another study showed that in Aβ25-35 induced BV-2 cells, the protein and mRNA expression of PGAM5 and DRP1 were elevated, whereas that of OPA1 was decreased, suggesting that modulation of the PGAM5-DRP1 signaling axis may help to alleviate the damage and improve mitochondrial homeostasis in an AD cell model, thus exerting a protective effect (Zhang et al., 2024).