In addition, PGAM5 regulates mitochondrial autophagy by another pathway: the PINK1-Parkin pathway.PINK1 is a kinase associated with early-onset Parkinson’s disease, and PGAM5 protects PINK1 from cleavage by the mitochondrial proteasome by PINK1 migrating from the inner mitochondrial membrane to the outer membrane, where it binds to Parkin and completes the subsequent mitochondrial autophagy process. This evidence concerns the gene PRKN and Parkinson disease.