CRLF2 and obesity due to melanocortin 4 receptor deficiency: This finding suggests that obesity and GATA3 risk alleles may contribute to CRLF2 altered pre-B ALL (CRLF2-ALL) leukemogenesis and maintenance, through obesity-induced phosphatidylinositol 3-kinase (PI3K)/AKT and mTOR signaling (10).