CRLF2 and acute lymphoblastic leukemia: Interestingly, Hispanic and Mexican patients with pre-B ALL also present a higher frequency of CRLF2 lesions, such as P2RY8::CRLF2 and IGH::CRLF2 rearrangements or CRLF2 overexpression, than Caucasian, Asian, and African-American patients (7–9).