Here, we associated the GATA3 risk alleles with: a) susceptibility to pre-B ALL; b) the risk of developing pre-B ALL concomitantly with the overexpression of CRLF2; c) the nutritional status of pre-B ALL patients; and d) the event-free survival (EFS) and overall survival (OS) of patients. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.