This finding suggests that obesity and GATA3 risk alleles may contribute to CRLF2 altered pre-B ALL (CRLF2-ALL) leukemogenesis and maintenance, through obesity-induced phosphatidylinositol 3-kinase (PI3K)/AKT and mTOR signaling (10). Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.