TAMs are important sources of epithelial growth factor within tumor tissue (141) and can also produce a variety of other cytokines, including platelet-derived growth factor, transforming growth factor beta-β, hepatocyte growth factor, and basic fibroblast growth factor (bFGF), thus promoting tumor cell proliferation and survival, acting as “signal transducers” in the interactions between tumors and neurons. This evidence concerns the gene FGF2 and neoplasm.