INS and Insulin resistance: In 1993, Surwit et al. (92) proposed that “The effects of stress on glucose metabolism are mediated by a variety of ‘counter-regulatory’ hormones that are released in response to stress and that result in elevated blood glucose levels and decreased insulin action.” Similarly in 2022, Sharma et al. (93) hypothesized that “The release of catecholamines and a rise in serum glucocorticoid concentrations caused by psychological stress enhance the requirement for insulin and insulin resistance.”