In this study, we aimed to evaluate the systemic levels of CRP axis, including pCRP, mCRP, IL-6 and IL-1β in various intraocular inflammatory conditions including diabetic macular edema (DME) and several types of non-infectious uveitis, comprising BD, BSRC, human leukocyte antigen (HLA)-B27-associated uveitis, and undifferentiated uveitis (UU). This evidence concerns the gene IL1B and uveitis.