SULT2A1 and rheumatoid arthritis: Importantly, when we specifically analyzed the untreated RA group (n=23), these hormonal reductions persisted without the confounding effects of medication, with aldosterone (-83%, FDR<0.001), cortisol (-21%, FDR=0.01), DHEAS (-50%, FDR<0.001), testosterone (-31%, FDR<0.001), DHT (-40%, FDR<0.001), and total estrogens (-44%, FDR<0.001) all significantly reduced compared to controls (Table 3).