By the way, our immunohistochemical data in nerve fragments corroborated the transcriptomic analysis, showing an increased inflammatory infiltrate, mainly in the endoneurium, through macrophage markers (CD68), as well as inflammasome proteins, such as ASC, IL-1β and NLRP-1 in PNL patients compared to non-leprosy control (Figure 4). Here, PYCARD is linked to leprosy.