Out of 252 dogs and 199 cats positive for E. coli infections, 31 dogs (i.e., 12.3, 95% CI: 8.8–16.9) and 25 cats (12.6, 95% CI: 8.7–17.9) had shown positivity for at least one toxin (CNF, CDT, LT, and ST); regarding verocytotoxins (vtx1, vtx2, eae), 18 dogs (7.1, 95% CI: 4.6–11.0) and 27 cats (i.e., 13.6, 95% CI: 9.5–19.0). Here, NPHS1 is linked to escherichia coli infection.