IL6 and osteochondritis dissecans: Chronic exposure to irritants, such as the herbicide 2,6-dichlorobenzonitrile (DCBN) can cause chronic elevation of nasal IL-6 levels, which results in damage to nasal olfactory mucosal supporting and basal cells and the inability of residual and repopulated basal cells to differentiate into ORNs, leading to a reduction in the number of olfactory neurons and impaired function; a mechanism that explains OD manifestations in patients with elevated IL-6 levels is clearer [101].