The findings suggested that IFN-I promoted neutrophil phagocytosis without affecting the chemotactic function, while baicalin inhibited the IFNα2-induced phagocytosis of neutrophils and promoted the chemotactic response of neutrophils, which was conducive to the aggregation of neutrophils to the site of infection or injury and played its immune defense functions. The gene discussed is IFNA2; the disease is infection.