The effective in vitro generation of 1O2 by the NIR‐illumination of the TMPyP4/G‐quadruplex functionalized UCNPs is displayed in Figure 5D, Panel I, and the effective gene silencing of the mRNA translated survivin in MCF‐7 breast cancer cells treated in the dark with the TMPyP4/G‐quadruplex/DNAzyme‐modified UCNPs or UCNPs modified with TMPyP4‐free G‐quadruplex/DNAzyme RCA chains, is presented in Panel II. Here, BIRC5 is linked to breast cancer.