This is exemplified in Figure 7D with the development of DOX‐loaded NMOFs gated by VEGF aptamer lock for the chemotherapeutic treatment of cancer cells.[137] Nucleic acid (7)‐functionalized UiO‐66 NMOFs were loaded with the DOX drug and the loaded particles were caged by DNA‐tetrahedra functionalized at one corner with the single strand tether (7’) complementary to the strand (7) associated with the NMOFs carriers. This evidence concerns the gene VEGFA and cancer.