IRF1 and acute respiratory distress syndrome: Moreover, the effects of IRF1 on 28-day survival (βindirect = −0.17, 95% CI: −0.31 to −0.02, 23.7% mediated, P = 0.021) and 60-day survival (βindirect = −0.20, 95% CI: −0.35 to −0.05, 27.9% mediated, P = 0.010) of ARDS patients were significantly mediated by attenuated acute physiology severity (Fig. 2F).