We observed a protective effect of IRF1 on 28- and 60-day survival in ARDS patients (hazard ratio [HR28-day] = 0.49, 95% CI: 0.28 to 0.84, P = 0.009; HR60-day = 0.55, 95% CI: 0.33 to 0.91, P = 0.019). This evidence concerns the gene IRF1 and acute respiratory distress syndrome.