Additionally, a significant protective effect of IRF1 on the survival of sepsis patients was also observed in the MARS cohort (HRper 1-SD = 0.76, 95% CI: 0.62 to 0.93, P = 0.008; HRHigh vs. Low = 0.64, 95% CI: 0.44 to 0.95, P = 0.025; Supplementary Fig. 2). This evidence concerns the gene IRF1 and Sepsis.