Based on the PhenomeXcan platform, we observed that IRF1 was significantly associated with ARDS-related traits in the UK Biobank (q-FDR ≤ 0.05), including eosinophil, platelet, white blood cell, monocyte, asthma, and lung function (Fig. 3A and Supplementary Fig. 3). Here, IRF1 is linked to acute respiratory distress syndrome.