In this way it could prevent PRC1 from exerting its repressive function, which can be detrimental as haploinsufficiency of other PRC1 components has already been associated with monogenic disease (e.g. oculofaciocardiodental syndrome caused by BCOR variants (MIM 300166), and Luo-Schoch-Yamamoto syndrome caused by RING1B/RNF2 variants (MIM 619460)). Here, RNF2 is linked to microphthalmia, syndromic 2.