However, the interaction between AD and diabetes is also driven by non‐vascular mechanisms, as insulin modulates synaptic plasticity and long‐term potential through the regulation of glutamatergic N‐methyl‐D‐aspartate receptor (NMDA) receptor expression and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor internalization.261. This evidence concerns the gene INS and Alzheimer disease.