However, the interaction between AD and diabetes is also driven by non‐vascular mechanisms, as insulin modulates synaptic plasticity and long‐term potential through the regulation of glutamatergic N‐methyl‐D‐aspartate receptor (NMDA) receptor expression and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor internalization.261. The gene discussed is INS; the disease is diabetes mellitus.