Early studies applied the administration of aluminum chloride (evoking neurotoxicity due to its ability to accumulate in the brain) to induce AD‐like pathologies, including an increase in Aβ concentration, phosphorylated tau, neuroinflammation, cognitive decline, and heightened systemic oxidative stress, all of which contribute to memory dysfunction,35, 36 without assessing the formation of Aβ plaques. This evidence concerns the gene MAPT and Mental deterioration.