In other cancers, biallelic loss of genes such as SDHC, TENT5 C, CUL3, CDKN2 A, CDKN2B, FAT1, SMARCA4, STK11, and KEAP1 was highly correlated with increased HRD scores, while TOP1, DNMT3B, ASXL1, PTPRT, SDHA, RAD21, and mismatch repair (MMR) core genes (MSH2, PMS2, MSH6 and MLH1) correlated with decreased HRD scores. The gene discussed is TOP1; the disease is cancer.