SIRT1 and osteoarthritis: Another study reported that down-regulated XIST was involved in the injury of chondrocytes during the pathophysiological process of OA, and XIST up-regulation protected chondrocytes from inflammatory injury via regulating miR-653-5p/SIRT1 axis [66].These regulatory network analysis results reveal the important regulatory roles of non-coding RNAs in the pathogenesis of osteoarthritis.