In the development of AD, cytokines including IL4, IL13, and IL31 play a crucial pro-inflammatory role and contribute to chronic pruritus [20]. Additionally, IL4 receptors (IL4R) and IL31 receptors (IL31R) on the dorsal root ganglion(DRG) are significantly involved in the transmission of itch sensation [35, 36]. The gene discussed is IL13; the disease is Alzheimer disease.