Results of this model indicated that higher VEGF level (IRR = 1.00, 95% CI 1.00 to 1.01, P < 0.001), history of intense abdominal pain (IRR = 1.57, 95% CI 1.18 to 2.10, P = 0.002) and family history of HAE (IRR = 1.57, 95% CI 1.04 to 2.38, P = 0.033) were associated with more frequent angioedema attacks, while receiving LTP was contributed to less frequent angioedema attacks (IRR = 0.30, 95% CI 0.20 to 0.46, P < 0.001). The gene discussed is VEGFA; the disease is angioedema.