SERPING1 and endothelial dysfunction: An animal study has demonstrated that administering an endothelial dysfunction blocker (CU06-1004) in SERPING1-deficient mice may mitigate vascular hyperpermeability by protecting the endothelial barrier function against bradykinin stimulation, suggesting that strategies aimed at protecting or stabilizing the vascular endothelium against bradykinin may offer an alternative prophylactic approach for HAE [35].