Mechanistically, adenosine produced by CD73 binds to the adenosine A2aR and activates Rap1, which recruits P110β to the plasma membrane and triggers the production of phosphatidylinositol 3-phosphate (PIP3), thereby promoting the phosphorylation of AKT in HCC cells [156]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.