CD73 is an ectonucleotidase that works with its upstream signaling molecule, CD39, to convert extracellular ATP into adenosine, which then binds to different adenosine receptors to regulate the immune system and exert anti-HCC effects; however, the associated mechanism has yet to be elucidated [130–135]. This evidence concerns the gene ENTPD1 and hepatocellular carcinoma.