NF-κB activation triggers inflammatory pathways, establishing a positive feedback loop with a rise in chemokine expression (e.g., CXCL8 and CCL2), nitric oxide synthase (NOS), COX-2, and inflammatory mediators (IL-6, IL-8, and TNF-α), thereby fostering tumor development [137]. The gene discussed is CXCL8; the disease is neoplasm.