A univariate analysis showed that age, TSC, AMLs, retroperitoneal LAMs, chylous effusion, HRCT grade, FEV1, FEV1%pred, FEV1/FVC, DLco, DLco%pred, PaO2 and P(A-a)O2 were significant factors for VEGF-D ≥ 800pg/ml. The gene discussed is VEGFD; the disease is tuberous sclerosis.