The current study was conducted to evaluate the role of the − 657 4G/5G PAI-1 polymorphism in pre-eclampsia patients in order to assess its role in influencing the onset of pre-eclampsia and its link to many pregnancy-related pathological problems, such as hypertension and elevated hepatic enzymes, in addition to elevated levels of oxidative stress in Egyptian women. The gene discussed is SERPINE1; the disease is hypertensive disorder.