The outcomes of the IVW analysis (Fig. 5) indicated that CFL2 (OR = 0.901, 95% confidence interval [CI]: 0.817–0.993, P = .036) was associated with PAS, with PIP5K1B (OR = 0.740, 95% CI: 0.570–0.961, P = .024) identified as a protective factor against arteriosclerosis. The gene discussed is CFL2; the disease is arteriosclerosis disorder.