Specifically, 8 immunophenotypes were associated with an increased risk of HF, including IgD+ CD38br AC, DP (CD4+CD8+) %leukocyte, CD28− CD127− CD25++ CD8br %T cell, CD28− CD127− CD25++ CD8br %CD8br, CD28+ CD45RA+ CD8br %T cell, CD19 on IgD+ CD38br, CD27 on IgD− CD38dim, and CD45 on lymphocyte. The gene discussed is CD4; the disease is hydrops fetalis.