Evidence for calcitonin and PCT secretion by the tumor accompanied by extreme calcitonin serum levels (>2000 pg/mL) was provided for 3 patients with pancreatic NEC.[14–16] Although we could not test for PCT or calcitonin secretion by the tumor itself, the serum concentration of calcitonin was 20.9 pg/mL, which is above the normal range (10 pg/mL), but well below the levels reported in the NEC patients mentioned above. This evidence concerns the gene CALCA and neuroendocrine carcinoma.