Blood and urine cultures remained negative, and local bacterial infections were excluded via an indium-111 WBC whole-body scan.[33] Huang et al reported a 67-year-old male with advanced intrahepatic CCA and multiple liver and lung metastases.[34] Serum PCT was increased (18.63 ng/mL), as were CRP (132.43 mg/L) and leukocytes (WBC: 52.8 × 109/L). This evidence concerns the gene CALCA and bacterial infectious disease.