Meegada et al reported an 80-year-old male patient with intrahepatic CCA and a history of chronic kidney disease (CKD stage III) and acute kidney injury who presented to the ED with abdominal pain.[33] PCT was elevated (35.6 ng/mL), along with symptoms of paraneoplastic syndrome such as hypercalcemia, polycythemia, and leucocytosis. This evidence concerns the gene CALCA and cholangiocarcinoma.