Basal PCT levels above 0.5 ng/mL are well documented for non-septic patients with primary lung cancer, especially those with neuroendocrine component and multiple metastases.[28–30] In addition, highly elevated serum PCT and calcitonin are frequently described for patients with neuroendocrine carcinomas (NECs) of the liver and pancreas.[13–16] Most of these patients had multiple liver metastases and presented with high fever. Here, CALCA is linked to lung cancer.