Integrating periodontal and orthodontic therapies in the management of periodontitis effectively improves anterior tooth displacement by reducing inflammatory markers such as NOD-like receptor protein 3 inflammasomes and high mobility group protein B1, facilitating bone repair, and ensuring long-term periodontal stability.[36,37] Controlling inflammation prior to orthodontic treatment is critical because tooth movement is safe during periods of stability but can exacerbate tissue damage during inflammation. The gene discussed is HMGB1; the disease is periodontitis.