The proportion of the effects of genetically-predicted psoriasis mediated by genetically-predicted ESAM, IL-16, and both ESAM and IL-16 was estimated as 24.8% (95% CI: 8.3%–41.2%), 16.1% (95% CI: 5.3%–26.8%), and 26.9% (95% CI: 6.3%–47.6%), respectively (Fig. 4). The gene discussed is IL16; the disease is psoriasis.