IL16 and psoriasis: Third, the key to mediation analysis depends on the correct formulation of the causal exposure correlations, because mediation and confusion are statistically indistinguishable.[50] Fourth, interpreting mediation analysis results for a binary outcome is not straightforward due to the non-collapsibility of the OR, as the estimate of the mediation proportion might be biased.[22] Fifth, we only found the mediating role of ESAM and IL-16 in psoriasis complicated with AMI from the perspective of genetics.