This study confirms that HaloPROTAC3 can induce the degradation of HT fusion proteins in the human hepatoma Huh7 cell line (Fig. 4 and Supplementary Fig. S5) and human primary hepatocytes (Supplementary Fig. S4), demonstrating that the host E3 ligase VHL can be harnessed for targeting the liver stages of human Plasmodium species. The gene discussed is VHL; the disease is hepatocellular carcinoma.