PPARGC1A and Cachexia: The EC PGC1α systemic overexpression (EC PGC1αsys-OE) also preserved IB4+ functional muscle vessels (Extended Data Fig. 10b) by increasing expression of PGC1α in muscle endothelium (Extended Data Fig. 10c) and restored mouse grip strength (Extended Data Fig. 10d) in B16F10-cachexia and CT26-cachexia mouse models.