Several of the 78 DDEGs, including Hey1, CCn3, CCn4, Smad6, Acta1, Myoz1 and Myoz2 are related to endothelial-to-mesenchymal transition (EndMT)30 (Fig. 3b), suggesting that the surviving muscle ECs undergo a phenotypic shift during cachexia progression. Here, SMAD6 is linked to Cachexia.