EC PGC1αim-OE in CT26-bearing mice also significantly prevented the loss of functional IB4+ muscular vessels, mouse grip strength, muscle mass and body weight (Extended Data Fig. 9p–t) without altering tumor growth and adipose mass when compared to controlim-OE CT26-bearing mice (Extended Data Fig. 9u–v). The gene discussed is DDX53; the disease is neoplasm.