PPARD and Cachexia: Interestingly, the downregulated genes in muscle ECs of B16F10-cachexia mice were enriched for multiple cofactors of the transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)γ coactivator 1α (PGC1α), such as Nrf1, PPARδ, Mef2, Hnf4 and forkhead box O1 (FOXO1).