INS and obesity due to melanocortin 4 receptor deficiency: Cifarelli et al. found that in women with obesity and lipedema (Obese-LIP) who lost weight with a moderate (~ 9%) diet, compared to women matched for age, BMI, and total body fat percentage, there was ~ 23% more leg fat mass, ~ 11% less android-gynoid ratio, and ~ 48% more insulin sensitivity.