USP10 and Parkinson disease: For instance, USP10 colocalizes with Lewy bodies (LBs) in the brains of patients with PD and promotes α-synuclein-containing protein aggregates (called aggresomes) with properties similar to LBs in cells treated with proteasome inhibitors, and USP10 overexpression increases α-synuclein levels in cultured non-neuronal cells (15).