METTL3 and glioma: As the most abundant internal modification in mRNAs, m6A broadly affects the central nervous system, regulating self-renewal of NPSCs, proliferation of glioma cells, development of brain, and growth of synapses.55 Knockout of the m6A writers METTL3 or METTL14 leads to impaired NPSC differentiation and prolonged cell cycle progression of radial glia in both mice and humans.56 Furthermore, m6A-mediated regulation was shown to be involved in learning and memory in mice.