Li et al. (2022) [48] mapped over 270,000 single-cell transcriptomes and demonstrated that the intratumoral heterogeneity of CD8+ T cell clonotypes exceeds that of somatic mutations, while also revealing an enrichment of epithelial-mesenchymal transition (EMT) at the tumor-normal interface co-localized with IL1B-expressing macrophages—potential targets for therapy [48]. Here, CD8A is linked to neoplasm.