Figure 6 also highlights virulence factors associated with Fn and Pg, including Fad 2 (adhesin and invasion), LPS, Fad A (adhesin), Fap 2 (fusobacterium autotransporter protein 2), and gingipains (cysteine proteinases), all of which could contribute to the development and progression of CRC. Here, JUP is linked to colorectal carcinoma.