[31] demonstrated that palmitic or oleic acids lead to the occurrence of such obesity‐related characteristics as a LD hypertrophy and insulin resistance, whereas only palmitic acid was able to increase adipocyte basal lipolysis and induce a shift in adipocyte secretome, making it capable of altering macrophage gene expression. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.