To investigate whether Sohlh1 inhibits Wnt/β‐catenin signalling pathway activation via regulation of SFRP1 expression, The TCGA database analysis showed that SFRP1 expression was significantly lower in glioma than in normal tissues (Figure 6A), and the CGGA database analysis showed a positive correlation between Sohlh1 and SFRP1 expression in glioma (Figure 6B). This evidence concerns the gene SOHLH1 and central nervous system cancer.