Meanwhile, a previous study revealed that meloxicam, a PTGS2 inhibitor, could alleviate mouse renal fibrosis induced by UUO through decreasing the expression of HSP47 and phosphorylation of extracellular regulated kinase (ERK) and c‐jun‐N‐terminal kinase (JNK), which play significant roles in the process of inflammation [47]. This evidence concerns the gene PTGS2 and renal fibrosis.