Meanwhile, a previous study revealed that meloxicam, a PTGS2 inhibitor, could alleviate mouse renal fibrosis induced by UUO through decreasing the expression of HSP47 and phosphorylation of extracellular regulated kinase (ERK) and c‐jun‐N‐terminal kinase (JNK), which play significant roles in the process of inflammation [47]. Here, MAPK1 is linked to renal fibrosis.