Gasdermin D was found to play roles in 2 more aspects of disease development in a colitis model in mice, as reported in a paper by Gao et al.19 Gasdermin D–deficient mice were found to have a less severe disease course, and the underlying mechanisms were found to include GSDMD-induced release of IL-18 and dysregulation of gut microbiota. Here, IL18 is linked to colitis.