These findings suggested that SNHG12 may function as an oncogene in NSCLC, which is consistent with the results obtained by Wang et al. 12 Results of previous studies demonstrated that SNHG12 participates in the tumorigenesis of NSCLC via the regulation of tumor cell function and reshaping of the tumor microenvironment.11,12 In the present study, NSCLC cell-derived SNHG12 promoted TAM2 polarization, leading to increased NSCLC cell proliferation, migration and invasion, and suppression of ferroptosis. Here, SNHG12 is linked to neoplasm.