SLC7A11 plays a role in importing cystine for glutathione biosynthesis and antioxidant defense.44 Notably, SLC7A11 acts as an oncogene in numerous cancers via antioxidant activity, suppression of excessive lipid peroxidation45 and regulation of metabolic reprogramming in the tumor microenvironment. This evidence concerns the gene SLC7A11 and neoplasm.