LncRNAs play a crucial role in tumorigenesis, functioning as oncogenes or anti-tumor genes in various tumors, including lung cancer.7–12 Results of a previous study revealed that lncRNA LINC00115 enhanced the proliferation, migration and invasion of lung cancer cells.30 However, lncRNA BRCAT54 promoted apoptosis and inhibited the tumorigenesis of NSCLC.31 In addition, lncRNA SNHG12 acts as an oncogene in renal cell carcinoma, colon cancer and NSCLC;12,32,33 however, the specific role of SNHG12 in esophageal squamous cell carcinoma (ESCC) remains to be fully elucidated. Here, MRPS30-DT is linked to esophageal squamous cell carcinoma.