CLOCK and Rett syndrome: These results are consistent with previous studies, which have recently reported that altered lipid and cholesterol biosynthesis is a hallmark of RTT (Pejhan and Rastegar 2021), that MeCP2 is involved in circadian clock regulation (Kyle et al. 2018) and that restoration of WNT signaling was beneficial in a RTT mouse model (Martínez de Paz et al. 2015).