ACTB and cancer: For example, ACTB (involved in RI events) influences cytoskeletal maintenance, cell migration, and immune cell function (Gu et al., 2021); RPS27A is involved in the cell cycle, immune response, and metabolism, and is closely linked to B- and T-cell antigen recognition (Li et al., 2024); AKT1 is linked to multiple splicing events, whose aberrant activation contributes to several cancers and may regulate immune cell function (Liu et al., 2014).