The objectives of this study were to determine the differences in protein levels related to the RAS in healthy controls and COVID-19 cases and to assess the role of ACE-inhbition, angiotensin receptor blockade and supplementation with angiotensin peptides involved in the RAS in cell death in the setting of in vitro SARS-CoV2 infection at differing conditions of drug delivery timing, concentration and viral concentration (MOI). Here, ACE is linked to COVID-19.