BDNF and obesity due to melanocortin 4 receptor deficiency: Ketogenic diet may improve metabolic and biochemical features of BD (271) such as reduction in oxidative stress and inflammation, improved mitochondrial function and biogenesis, improved glutamate/GABA transmission and reductions in intracellular sodium and calcium (273), increase of BDNF (274), reduction of BMI and control of obesity (275) and regulation of mood (276).