Ketogenic diet may improve metabolic and biochemical features of BD (271) such as reduction in oxidative stress and inflammation, improved mitochondrial function and biogenesis, improved glutamate/GABA transmission and reductions in intracellular sodium and calcium (273), increase of BDNF (274), reduction of BMI and control of obesity (275) and regulation of mood (276). This evidence concerns the gene BDNF and Obesity.