Li et al. (2012) showed that the rs2302254 TT mutation genotype frequency was 9.3% in the ovarian cancer patients, and the ovarian cancer patients with rs2302254 T/T genotype had a shorter survival time. However, little is known regarding the effects of NME1 genetic variants on CRC. In this study, we evaluated the contribution of the two polymorphisms of NME1 to the risk of CRC development and the clinical outcomes of CRC patients in a northern Chinese population. This evidence concerns the gene NME1 and ovarian carcinoma.