Zhao et al. (Zhao et al., 2024) demonstrated that N-acetylglucosaminyltransferase V (GnT-V) knockdown could reduce integrin β1 expression, inhibit downstream ERK1/2 activation, disrupt TGF-β1/Smads signaling pathway, and alleviate myocardial fibrosis induced by high glucose, accompanied by decreased expression of ANP, BNP and β-MHC. This evidence concerns the gene MAPK3 and Myocardial fibrosis.