CSF3 and Decreased total leukocyte count: Despite some high-risk patients receiving preventive supportive care with peg-G-CSF, the grade 4 adverse reactions primarily consisted of leukopenia (3 cases) and chemotherapy-induced neutropenia (CIN) (54 cases), while other grade 4 adverse reactions mainly included gastrointestinal symptoms (1 case of vomiting, 2 cases of diarrhea, and 5 cases of constipation).