Notoginsenoside R1 can reduce heart damage caused by high altitude hypoxia in rats by activating ERK1/2, in addition to increase Lgr5+ stem cell and epithelial healing in colitis mice by stimulating Wnt/β-Catenin signaling (Zhao et al., 2023; Yu et al., 2024). This evidence concerns the gene MAPK3 and colitis.