Exerted synergistic antitumor effectChemo-sensitization of HCC to low doses of lupeolUsing an in vivo HCC model, lupeol and S14161 synergistically inhibited tumor growth without any adverse effects on body weightActivated PI3-kinase/Akt pathwaySynergistically augmented anti-tumor effect of lupeol. The gene discussed is AKT1; the disease is hepatocellular carcinoma.