Caspase-3 dependent activationPoly ADP-Ribose Polymerase (PARP) cleavageSuppressed HCC cell proliferation via inhibition of BDNF secretion and phosphorylation of GSK-3β(Ser-9)Blockade of Akt/PI3K and Wnt signaling pathway. This evidence concerns the gene AKT1 and hepatocellular carcinoma.